Indications
Systemic Sclerosis
Interstitial Lung Diseases
Other Indications
Discovery
Preclinical
Phase 1
Phase 2
Systemic Sclerosis
Interstitial Lung Diseases
Other Indications
Systemic sclerosis (SSc) is a severe, rare, chronic autoimmune disease with high morbidity and mortality. About 80 percent of SSc patients are women. The disease process in SSc includes overactivation of the immune system with damage to small blood vessels and increased fibroblast activation resulting in fibrosis of the skin and internal organs, including lungs, heart, kidneys and the gastrointestinal tract.
Other indications of high interest for treatment with AM1476 or related compounds include interstitial lung diseases, liver fibrosis, cardiac fibrosis, fibrotic tumors as well as graft-versus-host disease.